Anita's on the Coastal Highway.
Another interesting food choice whenever in a given geographical location is to stop and see what's on the fast food menus. For example, at McDonald's in Chicago, you can get a Vienna-style Chicago dog. In Hawaii, they offer mango fruitpies. In Oceanside, we stopped at the local Wiennerschnitzel for some ice cream. They had a "seadog" on the menu, so of course we had to try it. It was pretty good. I'm not sure if every Wienerschnitzel offers seadogs, but I know our local one didn't (maybe it does now?).
Other than maybe a snack, however, we avoid any chains. Our rule of thumb when on vacation is to only eat local food. We follow the teachings of Anthony Bourdain: Be a traveler, not a tourist.
We heard about Roscoe's from an episode of No Reservations that found Anthony exploring the not-so-glamorous places of L.A. As we drove into Inglewood, the thought did come to Kulani and me that maybe we should turn around. Most of the businesses were boarded up and out of business; all the houses had bars on the windows and doors--it was looking scary, like something out of Boyz 'N the Hood. But we pressed on.